A male pseudohermaphrodite with a dicentric Y chromosome. Autoradiographic study.
نویسندگان
چکیده
A 13-year-old male pseudohermaphrodite (mixed gonadal dysgenesis, unilateral testicular differentiation) was found to be a chromosomal mosaic of the 45, X0/46, XY type, the Y chromosome being a symmetrical dicentric chromosome. Presumed ¥ chromosomes similar to this one have been observed before, but their identification was not supported by autoradiographic data. In the present study the identification of the dicentrie as a Y chromosome was supported by observing a relatively late DNA replication during the S period. The differentiation of testicular tissue on one side may be related to the presence of short arm material of the Y chromosome in the genome of the XYdic cells.
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ورودعنوان ژورنال:
- Humangenetik
دوره 6 2 شماره
صفحات -
تاریخ انتشار 1968